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Description

Neurons of the CNS are very active in oxidative metabolism, as they are constantly exposed to lowtomoderate levels of ROS, and these species are removed by antioxidants (melatonin, vitamin D, vitamin E, glutathione) and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, etc.)

547 A comprehensive and multidisciplinary analysis of post-mortem brain tissue in AD patients, including protein immunoblotting, elemental analysis, and metabolomics, showed that iron imbalance and elevated ferritin levels were associated with lipid peroxidation in AD patients

Utilizing genetic variants to personalize therapies will avoid this potential issue, and stratifying women based on risk of MASLD progression at menopause will identify those who would most benefit from pharmacological treatment