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Advanced technique: Some physicians approve splitting to twice-weekly smaller doses during peak side effect weeks (e.g., two 6mg injections instead of one 12mg)

Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism

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10.1038/srep39298

Relative Effects of Calorie Restriction+ and Weight Loss in Noninsulin-Dependent Diabetes Mellitus
