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The crystal structures of inhibitor-complexed forms also indicate that Gly-473 to Thr-475 forms an oxyanion hole, which interacts with the oxyanion of the tetrahedral intermediate in the transition state

Nakamaru Y, Akahoshi F, Iijima H, Hisanaga N, Kume T

143 The safety profile of tirzepatide is similar to other drugs in its class, providing an effective new treatment option for patients with T2DM and obesity

Integrin-linked kinase (ILK) activation drives osteogenic differentiation in umbilical cord MSCs, demonstrating pathway versatility