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Tumor-secreted extracellular vesicles regulate T-cell costimulation and can be manipulated to induce tumor-specific T-cell responses

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Vieira JO, Duarte JO, Costa-Ferreira W, Morais-Silva G, Marin MT, Crestani CC

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Spatial transcriptomic analyses reveal that DTX3L, an epithelial marker, and BST2, a stromal marker, are co-upregulated in esophageal squamous cell carcinoma, promoting M2 polarization and driving tumorigenesis, however their universality across cancer types remains to be validated (317)