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Second, there was no control group, so we cant rule out the possibility that the patients would have improved over time anyway

There are various treatment options available for melasma

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Furthermore, phase II studies were undertaken to prove the efficacy of mecasermin rinfabate (IGF-1/IGFBP-3) in paediatric severe burns and had promising outcomes when doses of 14 mg/kg/day [269273] were used

Lifestyle modifications and skincare tips Sun protection : Use broad-spectrum sunscreen daily with SPF 30 or higher and avoid direct sun exposure