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It is the match between the peptides mechanism and the patients specific clinical presentation, the quality of the 503A compounded source, and the structure of the protocol: loading, maintenance, rest, and follow-up built around the patients actual injury pattern and treatment goals

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Since superoxide anion cannot diffuse across the inner mitochondrial membrane it remains in the matrix which allows it to react with Fe-S groups in mitochondrial proteins resulting in the liberation of ferrous (Fe 2+ ) iron