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Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024

In MN, complement activation triggers mitochondrial dysfunction and ROS-mediated pyroptosis (122)

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Medication Levels for HG 1st Level Med ications for HG Antihistamine Acid reducers Vitamins B1 and B6 Meds successful in previous pg 2nd Level Med ications for HG Prokinetics: Reglan* (oral, low dose 5 mg) Acid blockers/PPIs (e.g