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These molecules are exposed to series of reactions such as condensation, ring formation, and hydrolysis

On comparing the activities of EcGGT (lid loop), BsGGT (no lid loop), and mutant BsGGT (lid loop), they concluded that entry of substrate into the active site was regulated by the lid loop depending on molecular weight

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This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF- and IL-6 (50)

Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity