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In contrast, at millimolar concentrations, GSH activates NMDA receptors by reducing functional thiol groups (Janky et al., 1993)

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marianensis and human homologs of hinT HN displayed a ~ 3-fold increase in binding affinity, with K D values of 9 nM and 10 nM, respectively (Fig

This indicates that the antioxidant system could prevent ferroptosis through mutual synergy or complementation

In men, MNP accumulation in the testes is accompanied by spermatogenesis disruption through pyruvate and thyroid metabolism imbalance [202], destabilization of the blood-testis barrier through ROS/MAPK/Nrf2/p38/NF-B activation [205], and suppression of the hypothalamic-pituitary-gonadal (HPG) axis through reduced testosterone and LHR/cAMP/PKA/StAR [52], clinically manifesting as oligozoospermia and asthenozoospermia, confirmed by the detection of PS, PE, and PVC in semen [207,208,209]