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Conclusion: Grx2s anti-apoptotic and cytoprotective roles may make it a potential drug target to treat oxidative stress-induced diseases Despite being overlooked, research throughout the years has portrayed Grx2 as a capable and robust antioxidant enzyme through direct detoxification of free radicals, cytoprotection, and anti-apoptotic abilities [5, 23]

Yamada T, Sato S, Sotoyama Y, Orba Y, Sawa H, Yamauchi H, et al

Without it, communication in the nervous system weakens, creating stress that may manifest as irritability, low mood, or heightened anxiety

Furthermore, atrophy and inflammation of mucosal surfaces in the gut are documented in experimental TD (82), and high doses of thiamine have been trialed in two studies showing that thiamine reduced fatigue associated with IBD (199, 200)

FIGURE 1 Cornus officinalis in DN The mechanisms of CO in treating DN mainly include regulating glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory, protecting podocytes, and regulating autophagy