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The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

Castilla-Cortzar I, Garca-Fernndez M, Delgado G, Puche JE, Sierra I, Barhoum R, Gonzlez-Barn S

The most common side effects are mild and include pain, redness, or swelling at the injection site

Some clinical protocols combine peptides rather than relying on just one: pairing CJC-1295 with Ipamorelin is used to boost growth hormone release for both fat loss and muscle gain, while combining a GLP-1 agonist with AOD-9604 pairs appetite reduction with direct fat-cell targeting

[2] In DIO mice, 5-Amino-1MQ was reported to reduce body weight and white adipose mass and to lower plasma cholesterol, without a measured change in food intake