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Specifically, after neonatal cardiac injury, adult-like fibroblasts (PDGFR + CD90 + Sca-1 + ) exhibited increased expression of fibrotic-associated genes ( Col1a1 , Col3a1 , Tgfb1 , and Tgfb3 ), whereas fetal-like fibroblasts (PDGFR + CD90 + Sca-1 ) had also increased expression of genes associated with improved cardiomyocyte proliferation ( Fn1 , Tbx20 , Igf1 , Igf2 , Fstl1) and neovascularization ( Vegfa) 155

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Amano, T., Nishihira, J

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

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