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these iron-containing structures serve as cofactors for numerous enzymes [1,2,3]

In mammalian cells, stress conditions lead to the upregulation of CHAC1 through the action of ATF4

CH 2 CH 2 CH 2 CH 2 , CH 2 CHCHCH 2 , CH 2 CsCCH 2 , CH 2 CH 2 CH(CH 2 CH 2 CH 3 )CH 2 , (CH 2 ) q N(R)(CH 2 ) r , wherein each of q and r is independently an integer from 0 to about 20, e.g., 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20, and R is hydrogen or lower alkyl

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

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