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More specifically, NRF2 and KEAP1 have been analyzed in postmortem motor cortex and spinal cord specimens from ALS patients and a reduction in both NFE2L2 mRNA and NRF2 protein has been found in ALS patient tissues when compared to control ones

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The findings demonstrated that the three treated groups experienced significantly reduced levels of urine 8-OHdG during both the 3-month and 6-month interventions, when compared to the placebo group

In addition, we conducted comparative studies based on the histological score (Table 2)

Future studies could be improved by defining precise asthma endotypes, involving multiple gene-gene interactions, and increasing sample size and power