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p53 activation can suppress the mitochondrial tricarboxylic acid cycle and oxidative phosphorylation through inhibition of malic enzymes 1/2 or by inducing a PUMA-dependent metabolic switch (Jiang et al, 2013

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As a consequence of this chemistry, O 2 - -dependent, SOD-sensitive chemiluminescence can be generated in cellular systems that do not generate ROS themselves but are simply capable of redox-cycling the probe (lucigenin) used to detect this activity

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