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A maximal locomotor effect resulted from 0.75 mg/kg METH in male rats, which was comparable to 0.32 mg/kg in females

Zhu JW, Ni YJ, Tong XY, Guo X, Wu XP

Notably, in the context of in vitro applications (where most preliminary data is gathered), the media is periodically replaced, thereby removing waste metabolites

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TPO is a key enzyme in the synthesis of thyroid hormone responsible for catalytic oxidation of iodine and iodization of tyrosine, and inhibition of TPO activity can directly lead to reduced thyroid hormone synthesis (Godlewska and Banga, 2019)