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Mechanistically, TCMPs enriched beneficial genera, enhanced SCFA production, suppressed NF-B and JAK/STAT3 pathways, upregulated tight junction-related genes, and inhibited NLRP3 inflammasome activation via microbiota-derived metabolites, collectively forming a microbiotametabolitehost regulatory network

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where S is the substrate (GSH), v is the reaction rate, k1 is the apparent first-order rate constant k1 was calculated based on the slope of fitted v -[ S ] curve