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Therefore, tocilizumab prolongs survival time in recurrent ovarian cancer ( Cancer-associated fibroblasts is an important component of the tumor microenvironment, which play a pro-tumor function in the process of cancer development, making it a hot spot of targeted therapy

This structural optimization led to the identification of Compound 32 , a highly potent indane derivative with improved PDE1B inhibitory activity (PDE1B IC 50 : 2.4 nM) (Figure 10)

Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue

PMID: 31554795 J Am Chem Soc2024 Apr 10;146(14):9779-9789

However, these tumors show increased activation of key pathways that promote and inhibit ferroptosis, suggesting that targeting drugs that promote ferroptosis could be an effective clinical target