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These processes result in the detachment of, among others, the ZO protein from the TJ complex and impair integrity of the TJ [16, 18, 66,67,68,69]

This strategy is particularly compelling as the activity of these autoinhibitory factors is increased in obesity, hinting at an etiological role for them in leptin resistance [15, 48,49]

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It is tempting to hypothesize that this 2:2 c-MET/HGF complex may exhibit higher activity than the 2:1 complex, due to the high structural stability

acquiring, retaining, and retrieving new information)
