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4 Alterations in the structural and functional characteristics of the GM The GM is intricately linked to health in the aged, as it may influence age-related alterations in innate immunity, sarcopenia, bone metabolism, and cognitive functionall of which contribute to frailty in older persons

Wang, H., Wang, A

Nevertheless, translating computationally predicted therapies into practice remains limited by difficulties in establishing causality, highlighting the need for more robust datasets linking dysbiosis to cutaneous pathogenesis and for direct functional validation

Peer review Peer review information Nature Communications thanks Minmin Liang, Yizhong Lu, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

doi: 10.1093/toxsci/kfx218 137 BelosludtsevKNIlzorkinaAIBelosludtsevaNVSharapovVAPenkovNVSerovDAet al