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Results of cellular thermal shift assay and molecular docking indicate that GPX4 is a potential direct target of carnosine, and carnosine shows promise as a potential inhibitor of ferroptosis for the treatment of renal I/R injury and other conditions associated with ferroptosis

NMR spectra were acquired using TopSpin and spectral intensities extracted using Topspin and Matlab functions

Lancet 377, 16631672

Third, to ensure target specificity and physiological relevance, we will utilize magnetic bead sorting to enrich CD14 + monocytes from clinical samples and establish AMI animal models with targeted gene editing to evaluate impacts on cardiac function and tissue remodeling

At high concentrations, direct parasympathetic cardiac inhibition overrides the baroreceptor-mediated reflex response, resulting in bradycardia with prolonged RR intervals on ECG