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Proteinase-activated receptors (PARs) are present on epithelial cells, monocytes, macrophages, and vascular endothelial cells, and their activation leads to the release of proinflammatory mediators including the cytokines TNF, IL-1, IL-2, and IL-6, and the chemokines CXCL8 (IL-8) and CCL2, all of which are associated with ARDS pathogenesis

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

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Yeong JL, Loveman E, Colquitt JL et al (2020) Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration