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First, growth hormones fat-mobilizing effect is coupled, in the intact hormone, to metabolically costly side effects: the same signaling that liberates fatty acids also raises circulating IGF-1 and can worsen insulin sensitivity, which is precisely why chronic growth-hormone administration is not a benign way to lose fat

Side effects are rare and usually mild, such as slight soreness at the injection site

seek veterinary care immediately if ingestion is suspected

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Previous studies showed that both experimentally induced circulating IGF-1 deficiency [14] and cell-specific disruption of IGF1R signaling in astrocytes [42] impair astrocyte-mediated NVC responses