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Experientia, 26 (3), 272 (1970)

Consistent with this early developmental stage, published clinical data - including a first-in-human phase I trial of INCB001158 alone or combined with pembrolizumab (NCT02903914) and a phase Ib study assessing INCB001158 with or without retifanlimab in Japanese patients (NCT03361228) - primarily report safety, pharmacokinetics/pharmacodynamics, and only limited antitumor activity in small cohorts [171]

It was originally developed as a potential anti-obesity drug due to its ability to influence fat metabolism without causing the same growth-promoting effects associated with full HGH therapy (review)

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