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The meta-analysis found that needles under 1 mm produced a larger pooled effect (SMD: 1.16) than needles over 1 mm (SMD: 0.52)

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88 This conclusion was further supported by the demonstration of a dramatic increase in nitrotyrosine staining and liver injury in MnSOD (SOD2) partial knockout mice, 90 as well as the elimination of nitrotyrosine protein adducts and liver injury in animals treated with mitochondrial-targeted SOD mimetics such as Mito-TEMPO 91 and Mito-Q
In fact, individuals who develop one are far less likely to develop the other [37]

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