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135 Tricellulin was found to be capable of localizing on a bi-cellular tight junction in occludin-knockdown cells and occludin-knockout mice to compensate for deficient bi-cellular tight junction-dependent barrier function of occludin

Its mechanism of action may be related to the inhibition of the Lyn/Snail signaling pathway (Cao et al., 2021), PI3K-AKT-mTOR (Ma et al., 2023) signaling pathway

View on PubMed Bergenstal RM, et al

(1998) Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism

The interplay can happen between enzyme system (UGT1A and UGT2B) and efflux transporters (both apical and basolateral) in enterocytes and hepatocytes as well as between the efflux and uptake transporters of hepatocytes (Liu and Hu, 2007