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Twisted epithelial-mesenchymal transition blocks senescence

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This intermittent drop-and-rebound pattern in oxygen levels is strikingly similar to what happens in ischemiareperfusion (I/R) injury, where tissue damage is caused not just by the lack of oxygen but also by its sudden return

An optimal antimalarial should not elicit resistance and should neutralize all parasite stages inside the human host, namely (i) hepatic forms associated to the asymptomatic onset of disease, (ii) dormant liver forms (hypnozoites) responsible for relapse in certain malaria types, (iii) blood-stage forms underlying the symptomatic phase of infection, and (iv) gametocytes, responsible for host-to-vector transmission

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