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exhibits anti-tumor activities, particularly against breast and bladder cancers (23, 24)

Fuehrlein BS, et al

10.11852/zgetbjzz2019-1045 Chin
As IRE1 is the most evolutionarily conserved UPR sensor, we investigated whether it also determines ferroptosis sensitivity in lower organisms

As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy
