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Upreti, G

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Nutritional intake plays an important role in mitigating this damage: on the one hand, the presence of essential fatty acids in membrane composition reduces cellular susceptibility to free radicals and serves as a primary defense against oxidative stress [51,52]

LRRK2 and PINK1 form a functional protein kinase pair to modulate TH and DA levels in dopaminergic neurons, and this observation has been validated in multiple in vitro and in vivo PD models, including human dopaminergic neurons and midbrain organoid models derived from patient cell-induced iPSCs [44]

Treg cells in the TME also display high levels of CD36, which is necessary to maintain their mitochondrial function and survival through PPAR- signaling (104)