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Metformin significantly activates AMPK signaling, reducing Th1 and Th17 cells while increasing Th2 and Treg cells (262)

Concerns about potential long-term risks associated with chronically elevated GH and IGF-1 levels include possible effects on cancer risk, as IGF-1 can promote cell proliferation and has been associated with increased risk of certain cancers in epidemiological studies, though causal relationships remain debated

Further studies of FMT application in CKD management, especially in restoring gut dysbiosis, reducing uremic toxins, inflammation, oxidative stress, and other markers of renal function, are needed

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