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Microbes can play a direct role in the activation and inactivation of drugs via biotransformation of drug molecules into secondary metabolites (Panebianco et al., 2018)

Human Microbiome of the Upper Gastrointestinal (GI) Tract Although the microbiome of the human lower gastrointestinal tract has been most extensively studied there are relevant bacteria in the upper gastrointestinal tract that includes the oral cavity and the esophagus

Cisplatin has been proposed to trigger ferroptosis 41 , but at the same time platinum compounds, like cisplatin and carboplatin, can have an iron depleting effect 81

The transformation is gradual to begin with, and will become more noticeable with time

Effects of short-term modified fasting on sleep patterns and daytime vigilance in non-obese subjects: results of a pilot study
