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We used WormExp 29 to compare these 234 genes to expression data from all previously characterized mutant animals and found they were significantly similar ( P = 1.7e107) to the gene set regulated by RNAi against sbp-1 (Supplementary Fig

In hypoxic environments, such as infarcted myocardium, vitamin C enhances the activity of prolyl hydroxylases (PHDs), which hydroxylate HIF-1 and promote its degradation [135]

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