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Description
The intrinsic pathway is initiated by cellular stress, such as DNA damage, resulting in release of cytochrome-c from the mitochondria causing activation of procaspase-9 through the interaction with apoptosis promoting activating factor-1 (APAF-1) and formation of an active apoptosome complex
doi: 10.1016/j.semcancer.2019.06.006 67 PandePZhongX-BKuWW
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer
Acta Crystallogr D Biol Crystallogr 66 , 1221, (2010)
By using the scientific software SigmaPlot (derivative), Enzyme Kinetics, (kinetics) subroutine, and the statistic analysis on SigmaStat
