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In parallel, oxysterol-driven destabilization of lipid rafts alters AMPA, kainate and GABAA receptor trafficking, impairing both phasic and tonic inhibition

83 Hemolytic crises occur in heterozygous female subjects, as well as in hemizygous male patients

For patients with severe, poorly controlled asthma, there is a clinical necessity to have a less complex nebulizer for home therapy to deliver both relievers and controllers using minimal inspiratory flow, especially for use at home or in ambulatory settings

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EMBO J 42:e112559