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Although increased glial cell activity may contribute to oxidative stress and apoptosis, microglial cells can be beneficial at times with autophagy induction to maintain cholesterol homeostasis (133), provide protection during amyotrophic lateral sclerosis (657), and for the clearance of amyloid in the brain (598)
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Among these, FAO reduction became critical for energy failure in the tubulointerstitial compartment, thus leading to inflammatory cell infiltration and tissue fibrosis (Xie et al., 2021)
PMID: 17138832
Schoderbeck M, Auer B, Legenstein E, et al
