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Further studies are also required to elucidate whether an increased GSH level in astrocytes in the brain could elevate the overall GSH content in the brain and whether such an intervention would affect the symptoms or modulate the progression of human neurological diseases

Thus, SGLT2 inhibitors might become a relevant therapeutic approach for hyperinsulinemia related conditions, other than T2DM, namely obesity and prediabetes

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Food Sci Hum Well (2022) 11(4):96574

A Phase 2 study published in the New England Journal of Medicine in 2023 (Jastreboff et al.) reported substantial weight loss in participants with obesity