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Evidence Synthesis Given heterogeneity in models, dosing, and outcome reporting, findings were summarized using structured narrative synthesis rather than quantitative pooling

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TLR4 activation, aberrant TLR4 signaling, and hyperinflammation may explain SARS-CoV-2-induced myocarditis and multiple-organ injury in COVID-19 patients (Aboudounya and Heads, 2021)

Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension