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Over-expression of metallothionein predicts chemoresistance in breast cancer
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Levels of KL-6 (a marker for AEC injury), ColIV1, and ColIV3 (markers for BM destruction) were significantly elevated in the serum of animals in the induced group, signifying that BLM caused AEC damage that resulted in the release of KL-6 23 and recruitment of inflammatory cells (e.g., monocytes) leading to the release of MMPs which results in further degradation of the surrounding BM and the release of collagen type IV fragments into the blood circulation 58,64
After 24 hr, adult worms were transferred to fresh plates and transferred daily until the end of the fertile period
10.1126/science.1158554 11 ChenK.KazachkovM.YuP
