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Greco et al
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doi: 10.3390/molecules16021055

Moreover, the lack of MTAN homologues in Euryarchaeota encoding an SAHH preferring SIH but also accepting SAH as substrate, strongly indicates that those enzymes have a dual function for SIH and SAH metabolism

In simple steatosis and early metabolic dysfunction-associated steatohepatitis (MASH), many of the body composition and metabolic features predisposing to MASLD/MASH contribute to decreased GH and IGF-I levels