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The compound was administered either through the tail vein (IV) or by oral gavage (PO)

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Hypertension has long been recognized as a leading risk factor for cardiovascular diseases (CVDs), which affect millions globally and leads to many morbidities and fatalities (Forouzanfar et al

Similarly, activation of CB 1 Rs and CB 2 Rs by synthetic cannabinoids [i.e., arachidonyl-2 -chloroethylamide (ACEA) and HU-308, respectively] reduced nitric oxide, TNF-, IL-1 and IL-6 release from spontaneous immortalized microglia (SIM)-A9 cells in culture (Young and Denovan-Wright, 2022a)

The interest in natural extracts has increased in the pharmaceutical, cosmetic and food industries due to their bioactive properties, claimed by the quickly growing market of antioxidant-containing healthy foods