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Patience proves essential, as premature discontinuation or excessive dosing frequently undermines therapeutic success

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[DOI] [PubMed] [Google Scholar] Bakker B., Bikker H., Vulsma T., de Randamie J

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(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

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