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10.1002/bdd.2510110205 3 ButterworthC

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More concerning are findings from systematic reviews and meta-analyses indicating dose-dependent hepatotoxicity and an increased risk of clinically significant liver enzyme elevations, especially when CBD is taken with drugs like valproate that share metabolic pathways

However, more extensive studies are needed to confirm these findings and establish safety and efficacy

Diagnostic Focus and Assessment Physical examination, and assessment of Numeric Pain Rating Scale (NPRS), Oswestry Disability Index (ODI), and Pain Self -Efficacy Questionnaire (PSEQ), were conducted during her initial visit, after six weeks and at 8-month follow-up