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Conclusion In the DSIP nasal spray vs injection debate, there is no strict winner. Both delivery forms of DSIP aim to support better sleep quality, deeper restorative sleep, and improved regulation of sleep-wake cycles and the circadian rhythm but they differ in how you use them and what trade-offs you accept

Trial Registration 207/19.09.2017 Similar content being viewed by others Digital Features This article is published with digital features, including a summary slide and video abstract, to facilitate understanding of the article

The effect seems to be related to the GLP-1 receptor agonists potency for weight loss

It is not yet a first-line recommendation

Injection site redness (mild, transient) Minor swelling at injection area Occasional headache Mild nausea (typically resolves) Fatigue during initial days Sleep changes (some report disturbance, others improvement) Increased appetite Vivid dreams Temporary digestive changes Sleep effects vary considerably among users