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Metabolomics analysis of human plasma reveals decreased production of trimethylamine N-oxide retards the progression of chronic kidney disease

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Network Biology and Polypharmacology of LC LC targets the expression of several genes throughout its production and biodegradations, and it also regulates the expression of several genes such as ACADM, ACADS, CPT1A, CPT1B, CPT1C, SLC25A20, CRAT, and BBOX1, and thus medium-chain acyl-CoA dehydrogenase is an enzyme made possible by the ACADM gene (MCAD)

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.OConnor D.A., Green S.E., Higgins J.P.T

Lactate accumulation acidifies the microenvironment, exacerbating ion dyshomeostasis and attracting neutrophil extracellular traps, web-like DNA structures that entangle MMP-9, amplifying BBB leakage [156] (Fig