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Possible explanations include unacceptable toxicity in human subjects, business strategy changes at Arrowhead Research Corporation (which shifted focus to RNA therapeutics), regulatory challenges, or a combination of factors
The labeled cDNAs were used to detect marker genes of signal transduction pathways on microarray membranes using Human Signal Transduction PathwayFinder RT 2 Profiler PCR Array (SuperArray System, Bioscience, Frederick, MD, USA)
Preclinical studies have shown that trazodone selectively inhibits neuronal reuptake of serotonin (Ki = 367 nM) and acts as an antagonist at 5-HT 2A(Ki = 35.6 nM) serotonin receptors
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