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These compounds allow therapeutic agents to permeate across biological membranes into systemic circulation and reach the site of action to exert pharmacological effect (Shaji and Patole, 2008)

After the staining was complete, the medium was replaced with fresh prewarmed complete medium and the cells were examined by confocal microscopy (Leica TCS SP5)

doi: 10.1007/s00424-017-2065-0 228 SchreiberRBuchholzBKrausA

PMID: 9282836, DOI: 10.1021/tx970035l

Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints