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A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease

As you can see, vitamin B12 is the junction between the methionine cycle and the folate cycle

10.1210/en.2010-0285 18 EyreH.BauneB

J Neurosci 23:26272633 Rao SD, Weiss JH (2004) Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

Epidemiological evidence accumulated since the discovery of folate, its sources and bioavailability has served as a foundation for translating knowledge into preventive and therapeutic public health strategies
