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To overcome the risks of genomic and chemical instability because of using nucleoside analogs, non-nucleoside DNMTs inhibitors have been tested as antitumor drugs in the last decade (Table 1)

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Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily

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