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In a small study involving older individuals, two weeks of supplementation with a combination of N-acety-l-cysteine (NAC) and glycine raised red blood cell (RBC) glutathione levels more effectively than either amino acid alone (Guthikonda, et al American Geriatrics Society,Annual Scientific Meeting, 2006.)

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Adult male SpragueDawley rats (Harlan, Madison, WI, USA) were implanted with jugular vein catheters under 2% isoflurane anesthesia and some rats received femoral arterial catheters 15,78,79