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When a pathogen invades, TNF receptor-associated factor 3 (TRAF3) ubiquitinates TBK1 to activate it, and activated TBK1 phosphorylates interferon regulatory factor 3 (IRF3) to induce type I interferon expression or sequestosome-1 (p62) to induce autophagy [27, 28]

Sections were stained with hematoxylin and eosin (H&E), FluoroJade C, or immunostained with antibodies

Carnosine can inhibit the binding of AGEs and RAGE, and block the activation of downstream signaling pathways, thus reducing the damage of AGEs to cells (55)

Impairing the radioresistance of cancer cells by hydrogenated nanodiamonds

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